After completing his studies, Jiří Voženílek focused on the standardization of residential buildings. His path led him to Zlín as early as 1937; however, due to the outbreak of the Second World War, he was only able to demonstrate his approach to standardization through the design of a single-family house.
After the end of the war, he worked together with the leading architects of the Baťa company to develop the general development and reconstruction plan for the areas of the factory complex that had been destroyed during the war.
Due to his left-wing political views, Voženílek became one of the most influential architects in Zlín after 1948, when Czechoslovakia came under communist rule. In 1949, he returned to Prague, where he worked for institutions such as Stavoprojekt (1949–1951) and the Research Institute for the Development of Architecture (Výzkumný ústav vývoje architektury, 1952–1955), which continued to advance standardization under state organization.
Alongside his teaching position at the Czech Technical University in Prague (ČVUT), he was also appointed chief architect of Prague.
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